Cancer: Sarcoma

Honokiol, isolated from the Chinese traditional herb magnolia, is a poorly water-soluble component and has been found to have anti-tumor properties.

Sarcoma

In the current study, honokiol submicron lipid emulsions (HK-SLEs) were prepared by high-pressure homogenization technology. After HK-SLEs were physically characterized, their pharmacokinetics, tissue distribution and anti-tumor activity after intravenous (i.v.) administration to tumor-burdened mice were examined, using honokiol solution (HK-SOL) as the control.

Both honokiol submicron lipid emulsions (HK-SLEs) and honokiol solution (HK-SOL) tended to accumulate in brain tissue. In vivo study showed that HK-SLEs treatment caused significant inhibition of mouse sarcoma S180 tumor growth compared to HK-SOL. These results suggest that HK-SLEs might be an effective parenteral carrier for honokiol delivery in cancer treatment (Zheng et al., 2013).

Reference

Zheng J, Tang Y, Sun M, et al. (2013). Characterization, pharmacokinetics, tissue distribution and anti-tumor activity of honokiol submicron lipid emulsions in tumor-burdened mice. Pharmazie, 68(1):41-6.