Cancer: Nasopharangeal., oral epidermoid, colorectal
Action: none noted
Ent-clerodane Diterpenoids are isolated from Scutellaria barbata (D. Don).
Nasopharangeal Cancer, Oral Epidermoid Carcinoma, Colorectal Cancer
Four new ENT-clerodane diterpenoids were isolated from the whole plant of Scutellaria barbata D. Don. (Labiatae). Their structures were elucidated by chemical methods and spectral analyzes. in vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal., KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range 3.1-7.2 microM (Dai et al., 2007).
Two new ent-clerodane diterpenoids have been isolated from Scutellaria barbata, and their structures were established by detailed spectroscopic analyzes as (13R)-6agr,7β-dihydroxy-8β,13-epoxy-11β-nicotinyloxy-ent-clerodan-3-en-15,16-olide (scutelinquanine D, 1) and (11E)-6agr-acetoxy-7β,8β-dihydroxy-ent-clerodan-3,11,13-trien-15,16-olide (6-acetoxybarbatin C, 2). In vitro, the isolated two new compounds showed significant cytotoxic activities against three human cancer cell lines (HONE-1 nasopharyngeal., KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range of 2.5-6.6 µM (Qu et al. 2010).
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