Cancer: Gastric

Action: Anti-oxidant, Anti-hemolytic

Ferula gummosa Boiss. (Barije) is an Iranian endemic plant growing in the northern mountainous regions. The gum extracted from the aerial parts of the plant has been traditionally used in the treatment of wounds, stomach pain and chorea. For the first time, anti-proliferative activity and apoptosis-inducing effects of ethanol extracts of the F. gummosa Boiss. leaf and flower were examined.

Gastric Cancer

The ethanol extracts were examined for their anti-proliferative and apoptosis inducing activity in human gastric cancer cell line, AGS, using concentrations from 10–70µg/mL.   F. gummosa Boiss. extracts inhibited the cell proliferation of AGS cell line in a dose-dependent manner with an IC50 of 37.47µg/mL for flower and 32.99µg/mL for leaf extracts. F. gummosa Boiss. extracts also induced apoptosis as shown by analysis of DNA fragmentation and plasma membrane translocation of phosphatidyl serine. F. gummosa Boiss. extracts exerted anti-proliferative as well as apoptosis induction effect in gastric cancer cell line. Further studies are needed for elucidation of the biochemical performance details and biological activity of the oleo gum-resin from Ferula gummosa Boiss which has shown acetylcholinesterase (AChE) inhibitory activity (Adhami et al., 2013).

Anti-oxidant, Anti-hemolytic activities

F. gummosa Boiss root showed different level anti-oxidant and anti-hemolytic activities. Biological effects may be attributed, at least in part, to the presence of phenols and flavonoids in the extract (Ebrahimzadeh et al., 2011).

References

Adhami HR, Scherer U, Kaehlig H, et al. (2013). Combination of bioautography with HPTLC-MS/NMR: a fast identification of acetylcholinesterase inhibitors from galbanum( ). Phytochem Anal., 24(4):395-400. doi: 10.1002/pca.2422.

Ebrahimzadeh MA, Nabavi SM, Nabavi SF, Dehpour AA. (2011). Anti-oxidant activity of hydroalcholic extract of Ferula gummosa Boiss roots. Eur Rev Med Pharmacol Sci, 15(6):658-64.

Gharaei R, Akrami H, Heidari S, Asadib MH, Jalilic A. (2013). The suppression effect of Ferula gummosa Boiss. extracts on cell proliferation through apoptosis induction in gastric cancer cell line. European Journal of Integrative Medicine, 5(3):241-247.