Cancer: Melanoma; metastasis

Ohno et al. (2009) suggests that acteoside injection, isolated from Plantago lanceolata showed suppressive effect on lung metastasis of B16 melanoma cells. Male C57BL/6 mice were injected intravenously with 2 x 10(5) of B16 melanoma cells, while acetoside at a dose of 50 mg/kg was administered intraperitoneally every other day from 13 d before B16 melanoma cell injection until all mice had succumbed to the metastatic tumor burden in the lung.

Administration of acteoside prolonged survival time significantly and the average survival time was 63.3 +/- 3.4d compared with 52.1 +/- 2.5d in control mice.

Reference

Ohno, T., Inoue, M., Ogihara, Y., Saracoglu, I. (2012) Anti-metastatic activity of acteoside, a phenylethanoid glycoside. Biological & Pharmaceutical Bulletin, 25(5):666-8. doi: 10.1248/bpb.25.666